Professor Megumu K. Saito, from the Department of Clinical Application, has spearheaded a research team that delved into the intricate world of transcriptional and epigenetic changes during definitive hematopoiesis. Their groundbreaking study sheds light on the indispensable contributions of ZEB2 and MEIS1 in generating hematopoietic stem cells from the hemogenic endothelium. The team’s findings have been published in the esteemed journal iScience.
Hematopoiesis, the process by which blood cells are formed, is a complex series of events crucial for maintaining a healthy immune system. Definitive hematopoiesis, in particular, plays a vital role in producing the diverse repertoire of blood cell types needed for proper bodily function. However, the molecular mechanisms governing this intricate process are not yet fully understood.
To unravel the mysteries of definitive hematopoiesis, Professor Saito and his team embarked on a comprehensive investigation of the dynamic transcriptional and epigenetic landscape involved. Transcriptional regulation refers to the control of gene expression, while epigenetics encompasses modifications to DNA and its associated proteins that influence gene activity without altering the underlying genetic code.
Their research uncovered the pivotal roles of two specific factors, ZEB2 and MEIS1, in orchestrating the transformation of hemogenic endothelial cells into hematopoietic stem cells—a key milestone in definitive hematopoiesis. These factors were found to be non-redundant, meaning each played a unique and essential role in this cellular conversion process.
ZEB2, a transcription factor known for its involvement in various developmental processes, emerged as a critical player in the generation of hematopoietic stem cells. It regulated the activation of genes necessary for enabling the transition from hemogenic endothelium to this specialized type of stem cell. The team’s findings highlight the indispensable nature of ZEB2 in driving this transformative event.
MEIS1, another transcription factor with crucial roles in embryonic development and organogenesis, also showcased its significance in definitive hematopoiesis. It was found to participate in epigenetic modifications that facilitate the generation of hematopoietic stem cells from the hemogenic endothelium. This discovery underscores the indispensable contribution of MEIS1 to this critical developmental process.
The research team’s investigation provides valuable insights into the intricate regulatory network governing definitive hematopoiesis. By deciphering the non-redundant functions of ZEB2 and MEIS1, they have advanced our understanding of how hematopoietic stem cells are produced from the hemogenic endothelium. These findings pave the way for future research aiming to unravel additional components of this complex molecular machinery.
By shedding light on the dynamic transcriptional and epigenetic changes underlying definitive hematopoiesis, Professor Saito and his team contribute to the growing body of knowledge in this field. Their study not only expands our understanding of blood cell development but also has implications for potential therapeutic interventions targeting hematopoietic disorders or regenerative medicine approaches utilizing hematopoietic stem cells.
Published in iScience, this groundbreaking research serves as a testament to the dedication and expertise of Professor Saito and his team. Their meticulous examination of the molecular intricacies involved in definitive hematopoiesis brings us one step closer to unraveling the fundamental mechanisms governing the formation of hematopoietic stem cells—a vital achievement in the pursuit of improved healthcare and medical treatments.
